Director, Institute of Cellular Medicine Professor of Clinical Rheumatology Newcastle University UK John Isaacs is Director of the Institute of Cellular Medicine at Newcastle University and consultant rheumatologist at the Freeman Hospital. He graduated from London University with a first class degree in Physiology and Medicine, followed by junior posts in London (Hammersmith Hospital) and Harvard (Beth Israel Hospital). He read for his PhD in Immunology at Cambridge. Over the past 20 years he has studied the potential of novel immunotherapies to treat rheumatoid arthritis, ranging from target identification to early and late-stage clinical trials. He has performed several pioneering translational studies, challenging existing dogma and informing the design of subsequent generations of therapeutic agents. In 1999 he received the British Society for Rheumatology Michael Mason Medal. In 2010 he presented the Heberden Round to the Society. Nationally, he chairs Arthritis Research UK’s Clinical Study Group for Inflammatory Arthritis, developing an internationally competitive research strategy for the UK. He also leads the MRC/ABPI £4.5m Immunology and Inflammation initiative, ‘seeking a cure for inflammatory arthritis’. He is a member of the Committee for the Safety of Medicine’s Expert Advisory Group on Clinical Trials.